![]() Another and more potent AT 1 receptor antagonist, L158,809, showed significant inhibition at 100 nmol/L, and at 10 μmol/L it inhibited basal aldosterone secretion (from 144.7☑8.2 to 83.4☑7.1 pg/10 6 cells per hour 42% inhibition). EXP 3174, an active metabolite of DuP 753, also inhibited aldosterone dose dependently (from 88.6☗.1 to 55.9☘.4 at 1 μmol/L and 88.6☗.1 to 21.7☓.3 at 100 μmol/L 37% and 75% inhibition, respectively). DuP 753 (10 μmol/L) inhibited basal aldosterone secretion (from 88.6☗.1 to 54.8☙.6 pg/10 6 cells per hour 38% inhibition). Zona glomerulosa cells were cultured in PFMR-4 medium containing 10% fetal calf serum for 72 hours, and the medium was replaced with serum-free medium for the next 24-hour experimental period. In this study we examined the effects of the AT 1 receptor antagonist DuP 753 and other antagonists on aldosterone secretion in cultured bovine zona glomerulosa cells. The actions of circulating angiotensin II (Ang II) are mediated by the activation of the Ang II type 1 (AT 1) receptor on the adrenal cortex. ![]() Customer Service and Ordering InformationĪbstract The zona glomerulosa cells of the adrenal gland have an intrinsic renin-angiotensin system that appears to modulate the aldosterone response to potassium and corticotropin.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
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